In children with schizophrenia, behavior changes may occur slowly, over time, or have a sudden onset. Slightly more males develop schizophrenia in childhood however, by adolescence, schizophrenia affects males and females equally. There appears to be a different threshold of expression, which means that one gender is more likely to show the problem, over the other gender. Often, one gender (either males or females) is affected more frequently than the other in multifactorial traits. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Multifactorial inheritance means that "many factors" are involved. Schizophrenia is considered to be multifactorially inherited. However, it is likely that many factors ? genetic, behavioral, and environmental ? play a role in the development of this condition. It is believed that a chemical imbalance in the brain is an inherited factor that is necessary for schizophrenia to develop. There is no known single cause responsible for schizophrenia.
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